ID Automotive Engineering Is Now ID Automotive Repairs | Auto ...

From PRWEB via Yahoo! News

ROCKINGHAM, WESTERN AUSTRALIA (PRWEB) August 11, 2012 ID Automotive Engineering, the trusted mechanic in Rockingham, today announced the change in the company name to ID Automotive Repairs with a view to reaching out to the target customers effectively. Founded about 5 years ago at Port Kennedy, the company has been catering to the automotive needs of its vast customer base. The company handles all kinds of automotive repairs?

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Source: http://autoecommerce.org/id-automotive-engineering-is-now-id-automotive-repairs/?utm_source=rss&utm_medium=rss&utm_campaign=id-automotive-engineering-is-now-id-automotive-repairs

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Get Great Advice On Home Improvement Projects ? They All Start ...

There are not many types of projects that bring as much satisfaction as home improvement projects. Your house is your personal castle, and when you put effort into it, you will feel wonderful. But how can you begin? The advice in this article will help you with ideas and techniques to put your house in the best shape.

Replacing the flooring in any room can be an expensive project. One alternative to save some money would be staining the bare concrete. This will give your home a modern and industrial aesthetic that can work well with a variety of different decors.

Cut off the extra length on your blinds? cords. Pets and children are easily entangled in long blind cords and can get strangled by them. Allow only enough cord to properly manipulate the blinds. Shorten it by tying or cutting before an accident occurs.

If you have made arrangements for one friend to be helping you on your home improvement project, be sure and have a second one in mind in case the first one cannot make it, for one reason or another. This will help to reduce the risk in case the person you choose does not work out well. That applies to this situation.

Installing insulation in the attic is a great way to cut the cost of heating and cooling a home. If the insulation of your attic is not good, you might be losing a lot of heat in the winter. Insulation is available at your nearest hardware store; you can install it yourself.

When contemplating a landscape project, it is essential that you choose a design style that will complement your home. Having a patio and a garden that go with your home?s style look nice.

It is always wise to draw up an estimate of the costs involved with any home improvement project. The homeowner could save a lot of cash by purchasing materials in bulk. Planning ahead can also ensure you have all the materials you need. Failing to order them in advance can stall your project.

You can use drywall mud to add texture and visual interest to your walls. This will also cover up any nicks or blemishes. It is quite easy to do. Use a trowel to apply the joint compound, and then dab with a sponge, brush, or a crunched up newspaper to add some texture.

Consider upgrading appliances as a simple home improvement option, in order to save money on utility bills. Installing new appliances, in place of your old ones, can save energy, thus saving on utility bills. It is pretty easy to install appliances, making this project a smart, efficient method of home improvement.

Any renovation of the kitchen or bathroom plumbing or fixtures should start with shutting off the supply of water. That may sound like a no-brainer to you, but it is a step that is often overlooked by homeowners, resulting in costly flooding.

Browse magazines and shops to find good ideas about home improvement projects. Head to your favorite decorating site or an old-fashioned library to get ideas quickly. Be sure to bring home samples of different colors to help yourself develop a color scheme that you will be happy with. Exploring your different options and figuring out which ones are best for your situation can make the project itself move a lot faster and more smoothly.

If you are thinking of purchasing a home, hire a professional inspector to check it out. By doing this, you do not have to look for everything that needs to be replaced or fixed. Enlisting a professional inspector who does not have a stake in the sale is a smart method of keeping things honest.

Paint the walls for an updated room or house look. A simple coat of paint will transform a room quickly. It is inexpensive to do and will boost the value of the home. Trying out softer colors will brighten your home and make it feel bigger.

Your home is your castle, your headquarters, your life. That is why taking care of it is so important. Remember the suggestions you just read?you should find them helpful. So think about what you really want to do to your home and make the improvements that are going to make you happy.

For all your marketing needs, check out SIVA marketing.

Source: http://www.theyallstartsomewhere.com/index.php/get-great-advice-on-home-improvement-projects/

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Be Competitive By Learning The MLM Recruiting - Small Business ...

If you want to succeed in running your own networking business, the first thing that you have to learn is the proper way of MLM recruiting. This is the process where you will convince people to sign up or join your MLM Company. This is also where you try to widen your connection in the online world by getting as much support as you can, in order to stay competitive with the other companies out there. By having the full support of your target market, this will somehow assure you of making your online business relevant in the industry, and stay above over your competitors.

Source: http://www.smallbusinessmarketingcd.com/latest-business-news/be-competitive-by-learning-the-mlm-recruiting/

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Who is Rep. Paul Ryan?

Rep. Paul Ryan, R-Wisc., leaves the House Republican Conference meeting, beginning at the Capitol Hill Club on??

Gov. Mitt Romney will announce Saturday morning that he's chosen 42-year-old Paul Ryan to be his running mate. Since 2008, the well-spoken Republican Congressman from Janesville, Wisconsin has emerged as a leading figure on the right and a champion of reduced government spending.

Ryan has earned the admiration of conservatives for the tough, government-slashing budget proposals he's put forward since becoming chairman of the House Budget Committee last year.?But when he first arrived in Washington as a freshman lawmaker in 1999 at only 28 years old, budget shrinking wasn't exactly in style.

Ryan told the New Yorker that he was "miserable" during the George W. Bush years, when a Republican-majority Congress added $5 trillion to the debt in war spending, bank bailout, tax cuts, and other costs. But Ryan also tended to vote with the majority at that time, though he put forward unsuccessful proposals to privatize Social Security and made other budget-shrinking suggestions.

In 2008, he released his "Roadmap for America's Future," which described his sweeping vision for how to make America's main entitlement programs of Medicare, Social Security and Medicaid solvent. The plan made him a hero among conservative circles, and Ryan eventually remade it as his "Path to Prosperity" plan, which President Obama and Democrats have criticized for embracing tax cuts while cutting government programs that help the poor. (It wasn't just Democrats who criticized Ryan. While running for president, Newt Gingrich called Ryan's plan "right wing social engineering," which probably helped kill Gingrich's bid.)

President Obama actually helped raise Ryan's profile on the right by critiquing the Congressman's budget, and just last year, Ryan was?reportedly mulling his own run for president.

Ryan, an Ayn Rand fan, ably articulates a conservative vision for economic growth; a mark that Romney occasionally misses as he dodges the subject of his own personal wealth. "I think [Obama] looks at the economy as a fixed pie, and that it's government's role and duty to redistribute the slices in the name of equity versus our belief, which is 'Let's just grow the pie' and have an opportunity in our society for upward mobility ? a society defined by upward mobility, not equal outcomes," he told Esquire magazine last year. "Under our view, we want to make sure people can get the opportunity to make the most of their lives, but that necessarily means that under the kind of economic-freedom system that we have had, you will have different outcomes of people's lives. And that's fine."

Ryan, who spent his early political career working for Kansas Sen. Sam Brownback and the late Republican Congressman Jack Kemp, grew up the fourth child in a Roman Catholic family in Janesville that has lived in the town for five generations. He worked in his family's construction business after earning his degree in economics from Miami University in Ohio. His father died when he was only 16, which prompted soul-searching that led Ryan to discover the works of Rand, who is still a major influence on him. He and his wife, Janna Little, have three children.

Source: http://news.yahoo.com/blogs/ticket/paul-ryan-063300661.html

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You may now switch the bride | The New York World

On a sunny spring day almost 15 years ago, Stephanie Diaz and her fianc? decided it was time to get married. They drove from the Bronx to the New York City clerk?s office, a high-ceilinged marble hall in downtown Manhattan, to get a license to wed.

But when the couple handed in their application, they were met with a rude surprise. The clerk refused to grant them a marriage license because her records showed that Diaz already had a husband. She had supposedly tied the knot a year earlier with a man named Lorenzo Guevara ? a man neither Diaz nor her fianc? had even heard of.

?We both looked astonished at each other,? said Diaz, who had never been married. The clerk ?explained to me that there was nothing she could do, and right then and there is when I started to cry.?

Stephanie Diaz, here with her daughter Megan Rosa, fought for 10 years for her right to marry after an identity thief took it away. Photo: Sasha Chavkin

Diaz was a victim of an audacious form of fraud that has altered the life course of hundreds of people in New York City and likely affected more nationwide. In the scam, unsuspecting victims of identity theft are impersonated at the altar. The thief or an associate will assume the victim?s identity, and for a fee, will get married in the victim?s name to an undocumented immigrant who is seeking United States citizenship.

The New York City Clerk?s office has rejected at least 1,769 marriage applications since October 2006 because prospective brides or grooms had prior marriages on record. In that time, 249 brides and grooms have appealed on the grounds that the marriages were fraudulent.

Clifford Holmes, a civil servant, discovered he was married three times, to women named Ramnattie Busgith, Dutrice Venthronia Baker and Ayana Muhammad. Lisa Betancourt of Queens turned out to be married to men from the Dominican Republic and Nicaragua. Theresa Ramirez, listed on her 1995 marriage license as a travel agent from Queens, was in fact a full-time caretaker for her quadriplegic father in the Bronx.

?They took one of these transcripts out of the computer and they said he was married not once but twice,? recalled Virginia Bond, whose fianc? Willie Nelson Portis was denied a marriage license in 2009. ?I?m looking at him and he?s like, ?That?s not true!?

Most city and county clerks let such oddities slide when couples who wish to get married apply for a license. The transaction relies upon trust: the bride and groom show their IDs, pledge that they are not already married, and are promptly issued a license.

Chicago, Los Angeles and New York all add?another step. They run the names of prospective brides and grooms against a database of people already married by the city or county. If prior marriages turn up, the couple is denied on the spot. LA and Chicago county clerks say cases of verified phony marriages are few and far between. But in New York, the problem has gotten so out of hand that the City Clerk has set up a special unit just to handle identity theft claims.

Patrick Synmoie, the general counsel for the New York City Clerk, assists the would-be brides and grooms who discover to their shock that they have previously been wed. A lean, deliberative man with black-rimmed glasses, suspenders and an immaculate purple-and-white bowtie, he is the frontline responder to couples suddenly denied the right to get married.

?We?ve seen people come in and the bride and the groom are both upset, the bride starts crying because all their relatives are coming from out of town, they?ve rented this hall, and so on,? Synmoie said. ?There are real implications for this.?

The scam is particularly insidious, Synmoie points out, because there are few red flags that would alert someone to a change in their marital status, the way an unexpected credit card transaction might. Across America, an unknown number of people who think they are single are in fact legally wed ? and entirely unaware they?re hitched.

?If you think about it,? said Synmoie in his slow, contemplative voice, ?how would you know you?re married??

For those willing to investigate, clues are plentiful. Stephanie Diaz was a lifelong resident of the Bronx, yet she had been getting calls from creditors claiming that she was racking up debt at furniture stores in New Jersey. When the clerk told her that she was already officially married, she immediately suspected that it was related to the identity theft.

Diaz, at the time a mother of two, tackled the problem on her own. She went to the city Bureau of Vital Statistics, where she learned that someone had recently picked up a birth certificate in her name. Another city agency showed Diaz her marriage certificate ? a sloppy forgery that misstated her father?s birthplace and claimed she was a resident of ?Bronx, New Jersey.?

?You also see during the signature where she looked like she was going to sign her real name, and then she scratched and went and did the ?S,?? Diaz recalled.

But when she tried to get the marriage stricken from her record, she hit an impenetrable wall of bureaucracy. The clerk deflected her calls and eventually told her that the office couldn?t negate the marriage without records from the police showing that she was a victim of identity theft. ?I was given the runaround over and over and over again,? Diaz said.

So Diaz turned to the police. NYPD detectives tracked the fraud to a woman in New Jersey, and arrested the fake ?Stephanie Diaz? after convincing her to cross the Hudson River into New York. She held a valid New Jersey driver?s license, a social security card and health insurance, all in Stephanie Diaz?s name.

The woman confessed that she had bought Diaz?s personal information from a co-worker in a bar where she worked off the books, the detectives told Diaz. She had then collected a fee from an undocumented immigrant, Lorenzo Guevara, to marry him under Diaz?s identity. It turned out that the impersonator had come from the Dominican Republic and was also in the country illegally.

But Diaz would have to press charges in New Jersey, and before she could her doppelganger disappeared. Diaz gave up on trying to persuade the city clerk to renounce the false marriage. She also ran into difficulties with her real fianc?, which proved to be equally insurmountable. Two years after their failed attempt at a wedding, the couple split up, leaving Diaz to care for a family that had grown to three children.

She had never gotten married at all.

There is a reason that New York City is strict about issuing marriage licenses. The city also faces marriage fraud of a more traditional sort: United States citizens who agree, for a fee, to marry an immigrant seeking a green card. These scammers often marry multiple immigrants for money, earning them a nickname among the clerk?s staff: ?career brides? and ?career grooms.?

In one notorious case in 2003, City Clerk Victor Robles identified a Manhattan woman who had applied for 27 marriage licenses over two decades. Since then, the clerk?s office has required all applicants for a marriage license to undergo a records search dating back 10 years, as opposed to only one year of records at the time Diaz applied. That has allowed the clerk to weed out repeat brides and grooms before they are issued a license ? and also snared even more unwitting victims of identity theft.

Until a few years ago, unwilling brides like Diaz had no way to override their fraudulent marriages other than a costly legal proceeding against the city. Synmoie routinely witnessed the injustice. ?We saw ordinary working-class citizens of New York who were stuck with this problem,? said Synmoie, who emigrated from Jamaica as a child and then sought out a job in government. ?If you couldn?t afford a lawyer, then effectively you were being denied the right to get married.?

So in 2006, he joined up with colleagues at the clerk?s office and two other city agencies to set up a special program to hear appeals of marriage rejections. Since then, 249 brides and grooms have appealed on the grounds that the marriages were fraudulent.

The burden of proof is on the victim, who for a $25 fee can fill out an appeal form. The clerk mails them a petition to invalidate their previous marriage, which they must return with evidence, such as proof of residence or handwriting samples, demonstrating that the old marriage is false. The clerk passes on the packet to an administrative law judge to provide an independent recommendation as to whether the applicant should be allowed to get married.

The New York City Clerk?s records show that among 249 appeals of marriage rejections, 61 have been granted and 10 have been denied. More than two thirds of appeals remain unresolved ? suggesting that even the current system is leading many people who claim to be fraud victims to give up.

But the real Stephanie Diaz at last had an opening. By 2007, nearly a decade after she was rejected by the clerk, Diaz had met someone new. Though they weren?t ready to get married, she decided she had to clear her record once and for all. This time, Diaz was directed to Synmoie and told that he could help her to finally fix her problem.

Awkwardly, Synmoie, as attorney for the clerk?s office, is not only the point person for fraud victims seeking assistance ? he is also the opposing party in their legal case. He often asks them ? politely but point blank ? whether they are aware of the practice of American citizens marrying immigrants for money.

?You can?t just walk in and say, ?That wasn?t me,?? Synmoie said.

His interrogations left Diaz distraught. ?I was explaining the situation to him and he was basically battling me, arguing with me,? Diaz said. ?I was like ?OK, well is he on my side or is he trying to show that I?m lying???

Synmoie said he explains his dual role to people who file appeals and has taken several steps to make the process easier. He provides sample answers to help people fill out the petitions to strike prior marriages, and sometimes even reviews their submissions to the judges. ?We bend over backward,? he says, ?to help them make their own case.?

Diaz spent nearly a year collecting the necessary documents. She gathered old leases to prove her residency and her father?s death certificate to prove his birthplace, and submitted samples of her handwriting for analysis.

Finally, in December of 2008, she had her hearing. Diaz argued that the evidence proved that she had been the victim of identity theft.

A week before Christmas, Administrative Law Judge Kara J. Miller released her conclusions.

?Respondent presented an impressively thorough and organized defense,? the judge wrote of Diaz. ?Petitioner?s counsel? ? Synmoie ???did not challenge respondent?s credibility or documentary evidence.?

Diaz had finally won. Her decade-old marriage license was recognized as a fraud and no longer stands in her way. She doesn?t have plans to get married anytime soon.

?I actually had tears in my eyes because I knew that I would actually be able to get married,? she said. ?If I found someone to get married to.?

Source: http://www.thenewyorkworld.com/2012/08/10/switch-the-bride/

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Essential Tips In Making The Right Pick Among Teaching Agencies

There are a lot of teaching agencies sprouting from nowhere these days, with education having consistent demand for teaching personnel, the supply of teaching staff has proven to be a lucrative business. There are some which are purely in it for the money, while most are truly dedicated in helping learning institutions and teaching job-seekers. If you do not want to get scammed by bogus teaching agencies, provided here are tips that can surely help.

In the UK, there is such a thing as the Department for Education's Quality Mark. This special mark is given to teaching agencies that uphold the highest quality of standards in supplying skilfully competent teachers to their client schools, as well as help new teachers find the teaching positions that are perfectly suitable to their academic credentials and other requirements. This leads to the first tip which is to check if the agency has accreditation.

If you're coming from abroad, it's best if the agency has a program that will help you before your arrival, hence the second tip. Reputable teaching agencies help in their teachers' visa concerns, living arrangements and even in opening bank accounts. If your agency has provision for all these things then you're in good hands.

Third tip is to make sure that the agency knows your specific requirements for the teaching jobs that you want. It's rarely a good sign if the agency informs you that it lined you up for a position that's not at all what you have in mind. Basically what this means is that, it's more intent on serving its own interest instead of yours. Though it's great to have a job right away, you don't want to be forced into a situation that may compromise you as a professional.

Fourth tip is to conduct a background check on the agency's client schools. The number of schools in its listing is not a solid indication that the agency's really good, but it will be an advantage to you if you know its breadth because it can determine the rate of success the agency may have in finding the appropriate teaching job for you. Also, make the Internet your friend; it's the best source of performance reviews from previous clients. You don't need to just take the agency's word for it because naturally its desire is to draw more clients to their business. Through the World Wide Web, you can easily check if all the agency's claims are true.

If you do not want to get scammed by bogus teaching agencies, provided here are tips that can surely help.

Source: http://articles.submityourarticle.com/essential-tips-in-making-the-right-pick-among-teaching-agencies-287361

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T-Mobile loses subscribers, smartphones flat

NEW YORK (AP) ? The long slide of T-Mobile USA continued in the latest quarter, as the country's No. 4 cellphone company lost subscribers and struggled to sign people up for smartphones.

The company, a subsidiary of Germany's Deutsche Telekom AG, said on Thursday that it lost a net 205,000 subscribers in the second quarter, a record for the period.

Among phone subscribers under contract, it lost 557,000 subscribers, also the highest number of the second quarter. Phone subscribers on contract-based plans pay the most, and are the bread and butter of large wireless carriers.

T-Mobile's revenue from monthly fees on contract service fell 9 percent from a year ago. The larger wireless carriers ? Verizon, AT&T and Sprint ? all managed to increase this number in the second quarter.

While other big carriers rely on boosting smartphone use to raise monthly fees, the number of smartphone users at T-Mobile USA was flat from the first quarter, at 11.6 million.

Thanks to job cuts, T-Mobile continued to be profitable, with a second-quarter net income of $207 million, nearly flat compared with $212 million a year ago.

Overall revenue fell 3 percent from a year ago to $4.9 billion.

The strong dollar helped T-Mobile's results boost those of its German parent, which reports results in euros.

Last year, T-Mobile agreed to be bought by AT&T Inc., but the deal was blocked by U.S. regulators. During the quarter, CEO Philipp Humm resigned, and was replaced by Jim Alling on an interim basis.

Source: http://news.yahoo.com/t-mobile-loses-subscribers-smartphones-flat-144224609--finance.html

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Shedding light on Carfilzomib, a promising new multiple myeloma therapy

ScienceDaily (July 25, 2012) ? Researchers from John Theurer Cancer Center at HackensackUMC, one of the nation's 50 best hospitals for cancer, played leading roles in three separate multi-center studies with the new proteasome inhibitor carfilzomib published in Blood, a major peer-reviewed scientific journal.

Carfilzomib is a novel, highly selective proteasome inhibitor, a type of medication that blocks the actions of certain proteins (proteasomes) that cancer cells need to survive and multiply. Carfilzomib is also known by its branded name Kyprolis?.

On July 20th the U.S. Food and Drug Administration (FDA) approved Kyprolis (carfilzomib) as a new treatment for advanced multiple myeloma. The treatment was fast-tracked due to the unmet need in multiple myeloma.

The most recent Blood study, published online July 25, includes results from the open-label, single arm phase IIb 003-A1 study of single-agent carfilzomib for patients with relapsed and refractory multiple myeloma. Carfilzomib's New Drug Application (NDA) is based primarily on this study. This research, along with the two other Blood studies, may change the way multiple myeloma is managed for newly diagnosed and relapsed/refractory patients.

Phase IIb Clinical Trial Published in Blood

David S. Siegel, M.D., Ph.D., Chief, Multiple Myeloma was the lead investigator of this pivotal multi-center, phase IIb study involving 30 cancer centers in the United States and Canada. The trial evaluated 266 heavily-pretreated patients with relapsed and refractory multiple myeloma who had received at least two prior therapies, including bortezomib and either thalidomide or lenalidomide.

"We found that carfilzomib produced clinically significant responses with an acceptable safety profile in heavily pretreated patients with relapsed and refractory multiple myeloma," said Dr. Siegel. "Given the limited number of treatment options available to patients with advanced-stage multiple myeloma and the diminished prospects for retreatment once an agent has been utilized, we believe there is a significant need in this patient population."

Two hundred and sixty-six patients received single agent carfilzomib twice weekly for 3 out of 4 weeks. The study's primary endpoint was overall response rate (ORR; ?partial response) and secondary endpoints included clinical benefit response rate (?minimal response), duration of response (DOR), time to progression, progression-free survival, overall survival (OS), and safety.

ORR was 23.7 percent with median DOR of 7.8 months. Median OS was 15.6 months. Adverse events (AEs) were manageable without cumulative toxicities. The researchers concluded that durable responses and an acceptable tolerability profile in this heavily-pretreated population demonstrate the potential of carfilzomib to offer meaningful clinical benefit.

Phase 1/2 Results for Frontline Therapy for Newly Diagnosed Multiple Myeloma Patients

David H. Vesole, M.D., Ph.D., F.A.C.P., Co-Chief and Director of Research served as co-author of a study published on June 4th in Blood, which involved researchers from six leading cancer centers. The multi-center, open-label phase 1/2 study looked at carfilzomib in combination with lenalidomide and low-dose dexamethasone (CRd) as a frontline treatment for multiple myeloma.

"Triple-agent regimens with bortezomib, lenalidomide, and/or thalidomide are currently the preferred frontline strategy for newly diagnosed multiple myeloma. However, maintaining dose levels over time can be limited by the treatments' emerging toxicities," said Dr. Vesole. "This study demonstrated that the combination of carfilzomib, lenalidomide and dexamethasone is well tolerated and highly active for these patients."

The researchers enrolled 53 patients with newly-diagnosed multiple myeloma who had symptomatic disease. Patients received CRd induction therapy in 28-day cycles for up to eight cycles or until disease progression or unacceptable toxicity. After eight cycles, patients received maintenance CRd for up to 24 cycles and then moved to a single-agent lenalidomide.

During phase 1, the primary endpoints were safety and determination of the maximum tolerated dose of carfilzomib within the context of CRd combination therapy. Carfilzomib doses were escalated, while lenalidomide and dexamethasone were given at standard low-dose induction levels. Once the maximum tolerated dose of carfilzomib was reached, the researchers began Phase II with a primary endpoint of near complete response (nCR). Secondary endpoints were overall response rate, time on study, duration of response, progression-free survival (PFS), time to progression, overall survival and overall treatment toxicity.

Study results indicated that patients experienced a rapid and good initial response to CRd, and their responses improved as the trial continued. Of the 49 patients who completed four treatment cycles, 67 percent achieved at least nCR, with 45 percent in stringent complete response (sCR), defined as no detectable tumor cells or myeloma protein in the blood or bone marrow. Of the 36 patients who completed eight or more treatment cycles, 78 percent achieved nCR with 61 percent in sCR. Overall, 62 percent of trial participants achieved at least nCR, with 42 percent achieving sCR. The investigators also found PFS rates were 97 percent at 12 months and 92 percent at 24 months. All patients who achieved sCR continued to respond to therapy for a median of nine months, demonstrating the durability of responses to this regimen. Importantly, these periods of extended treatment were well tolerated, including low rates of peripheral neuropathy, a treatment-limiting side effect of bortezomib, the first-generation proteasome inhibitor.

Bortezomib is currently FDA approved to treat advanced multiple myeloma, however, it has been shown to cause peripheral neuropathy in approximately 38 percent of treated patients with subcutaneous administration.

Phase II 004 Clinical Trial Results for Advanced Myeloma

Dr. Siegel and Dr. Vesole served as co-investigators on an 18-center, phase II open-label efficacy and safety clinical trial, also known as 004, of carfilzomib in combination with Bortezomib, another proteasome inhibitor. The study was published in the June 14th issue of Blood.

"We saw significant responses in patients considered more difficult to treat, including those with more advanced disease and poor prognoses," said Dr. Siegel, the senior author of the study. "Our results support the potential use of carfilzomib in this patient population."

The researchers enrolled 129 patients with multiple myeloma who had relapsed following one to three previous courses of treatment. Patients treated with bortezomib were excluded, as it is in the same drug class as carfilzomib and its use might make the effect of carfilzomib more difficult to determine. The study's primary endpoint was overall response rate. Researchers also measured patients' responses at various intervals as well as time to disease progression, and recorded reactions (adverse events) to treatment.

The most common adverse events in the study were fatigue (62 percent) and nausea (48.8 percent), while 17.1 percent of patients developed peripheral neuropathy, mostly Grades 1 and 2. Peripheral neuropathy, damage to nerves that fan out across the body from the brain and spinal cord, causes pain and other symptoms; lower grades have less severe symptoms. Peripheral neuropathy has been reported in 37-70 percent of myeloma patients receiving other commonly used drug therapies.

"Our myeloma team is leading the way in innovative research that makes promising therapies available to our patients, while also continually testing new ways to improve patients' quality of life," said Andrew L. Pecora, M.D., F.A.C.P., C.P.E., Chief Innovations Officer and Professor and Vice President of Cancer Services, John Theurer Cancer Center.

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Story Source:

The above story is reprinted from materials provided by John Theurer Cancer Center.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. David S. Siegel, Thomas Martin, Michael Wang, Ravi Vij, Andrzej J. Jakubowiak, Sagar Lonial, Suzanne Trudel, Vishal Kukreti, Nizar Bahlis, Melissa Alsina, Asher Chanan-Khan, Francis Buadi, Frederic J. Reu, George Somlo, Jeffrey Zonder, Kevin Song, A. Keith Stewart, Edward Stadtmauer, Lori Kunkel, Sandra Wear, Alvin F. Wong, Robert Z. Orlowski, and Sundar Jagannath. A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma. Blood, July 25, 2012 DOI: 10.1182/blood-2012-05-425934

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2012/07/120725100054.htm

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Compensation controversy over 'Adriatic Alcatraz'

GOLI OTOK, Croatia (AP) ? It rises up from the pristine waters off Croatia's coast, a forbidding mound of rock known as the Adriatic Alcatraz.

The amount former political prisoners are being offered for each day they spent on this hell: $9.

The paltry compensation Serbia's government is granting people imprisoned by late Yugoslav dictator Josip Broz Tito in one of Europe's most notorious post-World War II labor camps has triggered outrage among many ? and threats of a lawsuit.

"It's miserable," said Bozdar Vulovic, one of the few living survivors of the Goli Otok, or Barren Island, camp that was created in 1948.

Nearly 600 prisoners of all ex-Yugoslav nations ? Serbs, Croats, Bosnians, Slovenes, Macedonians and Montenegrins ? are estimated to have died on the island from torture and disease; thousands suffered psychological damage from an infamous prison system that pitted the prisoners against each other in a battle for survival.

Goli Otok housed up to 16,000 political prisoners over an eight-year period. They ended up there after being accused by Tito's regime of expressing sympathy toward Josef Stalin and his hardline Soviet dictatorship. Tito, who espoused a more liberal brand of communism, broke with Moscow in 1948, earning him support from the West.

Some of the former Serb inmates are threatening to take the government to an international human rights court for what they say is meager compensation for the horrors they went through.

Others say they will reluctantly accept the offer because they have no time to waste on lengthy legal procedures.

"If you were my age, and if you were in bad health, what would you do?" asked 91-year-old Smilja Filipcev, who spent more than three years at Goli Otok as a woman prisoner.

Serbia has now belatedly decided to rehabilitate the victims of Tito's communist regime, including ex-dissidents, royalists and the Goli Otok inmates.

Authorities said they arrived at the $9 a day figure because Croatia had offered a similar sum. But that was 10 years ago when the money was worth much more. Croatia also gave its nationals "privileged" pension status that resulted in a much higher total package than the Serb one.

In 2003, Slovenia offered its ex-prisoners ?6,300 for each year spent on the island. The other former Yugoslav republics ? Montenegro, Bosnia and Macedonia ? have not yet compensated their nationals.

"The fear that we went through is something that should be compensated," said Vulovic, who was incarcerated on the island for nearly three years. "And great fear it was,"

The controversy in Serbia has revived painful memories of the island camp kept secret for decades. Its existence was largely ignored in the West because inmates were thought to be hardline pro-Soviet communists, not dissidents like the ones in the ex-Soviet gulags in Siberia.

Tito was the undisputed leader of Yugoslavia for 35 years until his death in 1980. Those who publicly declared support after the split with Moscow were summarily dispatched to the island, without a trial.

Vulovic, an 85-year-old Serb citizen who was born in Montenegro, said the inmates on Goli Otok had arranged a "welcoming event" for him and the other newcomers.

"They screamed at us yelling 'down with the scum' and beat us with their hands," he said. "At Goli Otok, we had to spy on each other, and we had to beat other inmates up if they ordered us to do so."

"We were beaten all the time, while working, going to breakfast or to lunch," he said, adding that neither the International Red Cross nor any other international humanitarian organization ever visited the island while he was there.

Vulovic said trivial acts could land people in the camp ? which was often compared to San Francisco's Alcatraz island because no one ever managed to escape.

"It was enough for someone to listen to radio Moscow, or privately say something good about Stalin, to be reported to the secret police and end up on the island," Vulovic said at his small Belgrade apartment with Stalin's portrait and the Bible side-by-side on a bookshelf.

"I was arrested when I was 17," Vulovic said. "The reason for my arrest was stupid. Somebody had written 'Down with Tito, long live Stalin' in chalk on the walls all over my neighborhood" in the Montenegrin seaside town of Kotor.

"According to the logic of the time, they thought that only high school students had access to chalk. So they arrested six of us from that neighborhood, and they beat us until we had to confess that we were the ones that had written those words."

In 1956, the island ended its days as a political prison and was turned into a high-security facility for the hardest criminals. Years after Tito's death, Croatia's tourist organization tried to reopen the 1.9-square-mile (3-square-kilometer) island for tourists willing to pay to re-enact the life of a political prisoner ? including hard labor, stale food and nights in solitary confinement.

The plan, which even had the support of some former inmates who offered to work as tour guides, was scrapped because of the protests by Goli Otok political prisoner organizations.

"This is where the infamous Goli Otok lynches started," said former inmate Vladimir Bobinac, 85, while interviewed at the island, describing a lane of prisoners forced to organize welcoming party for new inmates.

"People were badly beaten, some even died," Bobinac said. "They were beaten out of fear. Those who did not deliver the punches were beaten themselves."

Filipcev, who retains an exceptionally clear-mind in her advanced age, said she was sent to Goli Otok from Serbia because she refused to denounce Stalin in his clash with Tito.

"They loaded us onto freight cars, and we were off," she said.

"When we arrived, they opened the car doors and we saw the sea in front of us. They kicked us out of the freight cars, and we waited for a boat to come pick us up. They loaded us into the ship's hull. They didn't wait for us to go down the stairs, they pushed us down, and we fell on top of each other. Some women fainted; some had their legs and arms broken."

She said that on the island, all the prisoners, including women, were forced to hard labor, mostly digging stones in a quarry.

"There we had wooden boards, with handles on each end, used for carrying heavy loads," she said. "You would trip and fall down onto the rocks. If you got injured, they'd make you sit down and break rocks until your injury was better, and then they would put you back to carrying rocks."

She said that when released, she came back home to Serbia.

"At the time when I was arrested, my elder daughter was four years old, and my younger daughter was two, so when they saw me, the first thing they asked was 'Are you really our mother?'"

___

Dusan Stojanovic and Marko Drobnjakovic contributed from Belgrade, Serbia.

Source: http://news.yahoo.com/compensation-controversy-over-adriatic-alcatraz-072902047.html

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IGNOU 2012: IGNOU Cyber Law in Post Graduate Certificate Courses

IGNOU offers a Post Graduate Certificate in Cyber Law (PGCCL) that seeks to address the fast changing needs of knowledge society in cyberspace.The PGCCL programme enables the learner to understand, explore, and acquire a critical understanding of cyber law, develop competencies for dealing with frauds and deceptions (confidence tricks, scams) and other cyber crimes like, child pornography etc. that has been taking place via Internet.

The understanding of the subject also pertains to making the learner conversant with the social and intellectual property issues emerging from cyberspace, explore the legal and policy developments in various countries to regulate it and give learners in depth knowledge of Information Technology Act and legal frame work of Right to Privacy, Data Security and Data Protection.

This programme is offered in two modes, both distance and online. Learners can choose their mode of study. The online platform is available at www.ignouonline.ac.in/vel which has several innovative features like walk in admission, integrated multimedia courseware, e-counselling, online examination and assignment management system. Facility for online payment gateway is also available for registration. Once registered, the learners will have access to personalized learning space.

The six months programme can be completed in a maximum time period of two years. A graduate in any discipline or fourth and fifth year students of five year integrated LLB course having passed three years are also eligible to pursue this programme.

The last date to apply for this programme is 30th July 2012 without late fee and 14th August 2012 with late fee of Rs.200. Student Handbook and Prospectus is available in all the Regional Centers of the university as well as in the university?s headquarters and at the City Centre, YMCA building in CP, which can be purchased for Rs.100 and submitted along with the requisite fee in the form of a demand draft to the concerned regional center.

Source: http://www.ignou4ublog.com/2012/07/ignou-cyber-law.html

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